کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1395006 1501192 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel quinolines and pyrimido[4,5-b]quinolines bearing biologically active sulfonamide moiety as a new class of antitumor agents
چکیده انگلیسی

Some novel quinolines and pyrimido[4,5-b]quinolines have been synthesized. The structures of which were confirmed by elemental analyses and spectral data. All the target compounds were subjected to in-vitro antitumor activity against Ehrlich Ascites Carcinoma (EAC) cells. Compounds 24, 19 and 12 showed higher activity with IC50 values (5.5, 6.9, 7 μg/ml) when compared with Doxorubicin as a reference drug (IC50 value 38 μg/ml).

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 2, February 2010, Pages 738–744
نویسندگان
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