کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1395022 | 1501192 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates](/preview/png/1395022.png)
چکیده انگلیسی
We report synthesis, in vitro antiviral activity, and stability studies in biological media of original boranophosphonate isosteres of AZT and d4T monophophates. A convenient route for the synthesis of 3′-Azido-3′-deoxythymidine-5′-boranophosphonate 8 and 2′,3′-Didehydro-3′-dideoxythymidine-5′-boranophosphonate 12 is described. H-phosphinates 7 and 11, and α-boranophosphonates 8 and 12 exhibited no significant in vitro activity against HIV-infected cells, neither against a broad panel of viruses, up to 200 μM. The absence of activity of target compounds 8 and 12 can be partially explained by their short half-life in culture medium.
Nucleoside α-boranophosphonate analogues of AZT and d4TFigure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 2, February 2010, Pages 849–856
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 2, February 2010, Pages 849–856
نویسندگان
Karine Barral, Stéphane Priet, Céline De Michelis, Joséphine Sire, Johan Neyts, Jan Balzarini, Bruno Canard, Karine Alvarez,