کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1395056 | 1501200 | 2009 | 5 صفحه PDF | دانلود رایگان |

In order to improve biological behavior of the retinoyl derivatives, monoarylferrocenyl alcohols 9a and 9b were synthesized by an improved Suzuki cross-coupling method and their 13-cis-retinoic acid analogues were prepared in moderate to good yields via the Mitsunobu reaction. Their structures were confirmed by IR, 1H NMR, 13CNMR, MS spectra and element analysis and their antiproliferative activities were determined in vitro using human cancer cell lines. The results of bioassay showed that these organometallic analogues exhibited higher antiproliferative activities than parent 13-cis-retinoic acid and other retinoyl derivatives.
A series of new ferrocene-analogues of 13-cis-retinoic acid have been synthesized via the Mitsunobu reaction. Their structures have been characterized by spectra data. The results of bioassay showed that these compounds exhibited higher antiproliferative activities than parent 13-cis-retinoic acid and other retinoyl derivatives.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 6, June 2009, Pages 2572–2576