کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1395056 1501200 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, characterization and in vitro antiproliferative activities of new 13-cis-retinoyl ferrocene derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, characterization and in vitro antiproliferative activities of new 13-cis-retinoyl ferrocene derivatives
چکیده انگلیسی

In order to improve biological behavior of the retinoyl derivatives, monoarylferrocenyl alcohols 9a and 9b were synthesized by an improved Suzuki cross-coupling method and their 13-cis-retinoic acid analogues were prepared in moderate to good yields via the Mitsunobu reaction. Their structures were confirmed by IR, 1H NMR, 13CNMR, MS spectra and element analysis and their antiproliferative activities were determined in vitro using human cancer cell lines. The results of bioassay showed that these organometallic analogues exhibited higher antiproliferative activities than parent 13-cis-retinoic acid and other retinoyl derivatives.

A series of new ferrocene-analogues of 13-cis-retinoic acid have been synthesized via the Mitsunobu reaction. Their structures have been characterized by spectra data. The results of bioassay showed that these compounds exhibited higher antiproliferative activities than parent 13-cis-retinoic acid and other retinoyl derivatives.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 6, June 2009, Pages 2572–2576
نویسندگان
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