کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1395061 | 1501200 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and antinociceptive activities of some pyrazoline derivatives Synthesis and antinociceptive activities of some pyrazoline derivatives](/preview/png/1395061.png)
In the present study, some pyrazoline derivatives were synthesized to investigate their potential antinociceptive activities. 1-[(Benzoxazole/benzimidazole-2-yl)thioacetyl]pyrazoline derivatives were obtained by reacting 3,5-diaryl-1-(2-chloroacetyl)pyrazolines with 2-marcaptobenzoxazole/benzimidazole. The chemical structures of the compounds were elucidated by IR, 1H NMR and FAB+-MS spectral data and Elemental Analyses.All of the compounds (100 mg/kg) exhibited significant antinociceptive activities in both hot plate and acetic acid-induced writhing tests. Naloxone (5 mg/kg) pre-treatment reversed the antinociceptive activities suggesting the involvement of opioid system in the analgesic actions. None of the compounds impaired motor coordination of animals when assessed in the Rota-Rod model.These results support the previous papers reporting the opioid sensitive antinociceptive activities of various benzoxazole/benzimidazole–pyrazoline derivative compounds.
Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 6, June 2009, Pages 2606–2610