کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1395068 | 1501200 | 2009 | 4 صفحه PDF | دانلود رایگان |
The first simple and efficient approach towards one step synthesis of 2-amino-5-cyano-6-hydroxy-4-aryl pyrimidines has been developed by three component condensation of aromatic aldehydes, ethyl cyanoacetate and guanidine hydrochloride in alkaline ethanol. The synthesized compounds evaluated for their anti-bacterial activity against Gram-positive and Gram-negative bacteria. The some of the compounds showed excellent zone of inhibition against tested bacteria.
The first simple and efficient approach towards one step synthesis of 2-amino-6-hydroxy-4-(phenyl)-pyrimidine-5-carbonitrile has been reported by three component condensation of aromatic aldehydes, ethyl cyanoacetate and guanidine hydrochloride using alkaline ethanol. The synthesized compounds evaluated for their anti-bacterial activity against Gram-positive and Gram-negative bacteria.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 6, June 2009, Pages 2651–2654