کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1395184 1501202 2009 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and in vitro antitumor activity of new quinoxaline derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and in vitro antitumor activity of new quinoxaline derivatives
چکیده انگلیسی

A series of novel 5,7-diamino-3-phenyl-2-benzylamino, 2-phenoxy, and 2-thiophenyl substituted quinoxalines has been designed, synthesized and evaluated for their in vitro antitumor activity towards cell lines of nine different types of human cancers. Some of these compounds exhibited inhibitory effects on the growth of a wide range of cancer cell lines generally at 10−6 M, in some cases at 10−7 M and 10−8 M concentrations. Within this series the benzylamino quinoxaline derivatives 1b–7b were the most active, whereas compound 2c showed the highest MG_MD value (−5.66).

A series of novel 5,7-diamino-3-phenyl-2-benzylamino, 2-phenoxy, and 2-thiophenyl substituted quinoxalines have been designed, synthesized and evaluated for their in vitro antitumor activity towards cell lines of nine different types of human cancers.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 4, April 2009, Pages 1579–1591
نویسندگان
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