کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1395213 | 1501202 | 2009 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Anti-HIV evaluation of benzo[d]isothiazole hydrazones Anti-HIV evaluation of benzo[d]isothiazole hydrazones](/preview/png/1395213.png)
The synthesis and the anti-HIV-1 activity of novel benzo[d]isothiazole hydrazones are reported. Target compounds tested in MT-4 cells cultures for their anti-HIV properties against wild type HIV-1 and HIV strains carrying clinically relevant mutations (EFVR, Y181C and K103/Y181C) showed good activity against wild type HIV-1 and against the EFVR mutant. In terms of SAR the relevant result was that, in the class of benzisothiazole hydrazones, the benzo[d]isothiazol-3(2H)-one moiety (compounds 1 and 4) is an essential structural requirement for the antiretroviral activity.
The synthesis and the anti-HIV-1 activity of novel benzo[d]isothiazole hydrazones are reported. The presence of the benzo[d]isothiazol-3(2H)-one moiety (compounds 1 and 4) is an essential structural requirement for the antiretroviral activity.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 4, April 2009, Pages 1801–1807