کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1395213 1501202 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-HIV evaluation of benzo[d]isothiazole hydrazones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Anti-HIV evaluation of benzo[d]isothiazole hydrazones
چکیده انگلیسی

The synthesis and the anti-HIV-1 activity of novel benzo[d]isothiazole hydrazones are reported. Target compounds tested in MT-4 cells cultures for their anti-HIV properties against wild type HIV-1 and HIV strains carrying clinically relevant mutations (EFVR, Y181C and K103/Y181C) showed good activity against wild type HIV-1 and against the EFVR mutant. In terms of SAR the relevant result was that, in the class of benzisothiazole hydrazones, the benzo[d]isothiazol-3(2H)-one moiety (compounds 1 and 4) is an essential structural requirement for the antiretroviral activity.

The synthesis and the anti-HIV-1 activity of novel benzo[d]isothiazole hydrazones are reported. The presence of the benzo[d]isothiazol-3(2H)-one moiety (compounds 1 and 4) is an essential structural requirement for the antiretroviral activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 4, April 2009, Pages 1801–1807
نویسندگان
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