Design, synthesis and evaluation of a novel class of glucosamine mimetic peptides containing 1,3-dioxane

• Several novel glucosamine mimetic peptides containing 1,3 dioxane were designed and synthesized.
• Most of compounds exhibited a significant inhibition against xylene-induced inflammation in mice.
• Some compounds show similar the anti-inflammatory effect in comparison to positive control aspirin.

A number of novel 2-(N-(2-(5,5-dimethyl-1,3-dioxane-2-yl)ethyl)aminoacyl)amino-2-deoxy- d-glucopyranoside were synthesized from a readily available starting material, glucosamine, 2,2-dimethyl-1,3-propanediol and 1,1,3,3-tetramethoxypropane, and evaluated for their anti-inflammatory activity. Our results showed that all of the compounds tested exhibited a significant inhibition of xylene-induced inflammation in mice.

Some novel glucosamine mimetic peptides containing 1,3-dioxane were obtained and evaluated for their anti-inflammatory effect.Figure optionsDownload as PowerPoint slide