کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1395459 1501221 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41 as catalyst, and their biological evaluation as human platelet aggregation inhibitors
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41 as catalyst, and their biological evaluation as human platelet aggregation inhibitors
چکیده انگلیسی
A novel synthetic approach to N-aryl-4-(3-pyridyl)thiazol-2-amine and analogues using HMCM-41 and their in vitro ADP-induced platelet aggregation inhibitory activity on human blood platelets is described. Among the test compound, N-(2′-flourophenyl)-4-(3-pyridyl)thiazol-2-amine (9e) was found to be the most potent, IC50 = 4.84 × 10−7 M.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 42, Issue 8, August 2007, Pages 1144-1150
نویسندگان
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