کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1395510 1501126 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antiproliferative activity of novel polynuclear heterocyclic compounds derived from 2,3-diaminophenazine
ترجمه فارسی عنوان
سنتز و فعالیت ضد انعقادی ترکیبات هتروسیکلی جدید چند هستهای مشتق شده از 2،3-دیامینوفنازین
کلمات کلیدی
پنینیزین، ایمیدازول، دیازپین، پیازین، آزو، ضد انفوزیون
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• Novel heterocyclic compounds derived from 2,3-diaminophenazine were synthesized.
• All compounds were characterized based on microanalytical and spectral data.
• The compounds were screened for their antitumor activity against A549 and HCT116.
• Five compounds were mostly antiproliferative agents as potent as the Cisplatin.
• Compound 2 inhibited the TRK activity equal or more potent to the Cisplatin.

2,3-Diaminophenazine 1 was used as a precursor for the preparation of some novel phenazine derivatives such as imidazo[4,5-b]phenazine-2-thione 2, its methylthio 3, ethyl 1-aryl-3H-[1,2,4]triazolo[2,3-a]imidazo[4,5-b]phenazines 8a–c, ethyl (2Z)-[3-aminophenazin-2-yl)amino](phenylhydrazono)ethanoate 9, pyrazino[2,3-b]phenazine derivatives 10, 12, 15–17, [1,4]diazepino[2,3-b]phenazine derivatives 13, 14, 2,3-dibenzoylaminophenazine 18, 1H-Imidazo[4,5-b]phenazine derivatives 20, 23a–c, 24, 25 and 4-[(E)-(3-amino phenazin-2-yl)diazenyl] derivatives 27–29. All compounds were tested as inhibitors of the proliferation of human lung carcinoma and colorectal cancer cell lines through inhibition of Tyrosine Kinases. Most of compounds exert good activity against the two cancer cell lines. Five compounds (1, 2, 3, 25 and 28) were found to possess the same activity as the standard drug Cisplatin.

Novel series of phenazine derivatives were synthesized and evaluated as inhibitors of the proliferation of lung carcinoma (A549) and colorectal cancer (HCT116) cell lines through inhibition of human TRK activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 90, 27 January 2015, Pages 568–576
نویسندگان
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