Synthesis and antimicrobial activity of new bromine-rich pyrrole derivatives related to monodeoxypyoluteorin

The synthesis and antimicrobial activity of new pyrrole derivatives structurally related to monodeoxypyoluteorin are described. The insertion of a keto or methylene spacer between the phenol group and the pyrroloyl moiety of brominated 2-(2′-hydroxybenzoyl)pyrroles leads to a decrease of the antibacterial activity.

The synthesis and antimicrobial activity of new pyrrole derivatives related to monodeoxypyoluteorin are described. The insertion of a keto or methylene spacer in the bond between phenol group and pyrroloyl moiety of brominated 2-(2′-hydroxybenzoyl)pyrroles leads to a decrease of the antibacterial activity.Figure optionsDownload as PowerPoint slide