Synthesis and antimicrobial activity of amine linked bis- and tris-heterocycles

• Amine linked bis- and tris-heterocycles were prepared from heteroaryl cinnamamides.
• The compounds 11c and 12c exhibited excellent antibacterial activity while 12a and 12c displayed excellent antifungal activity.
• The presence of electron withdrawing substituent on aromatic ring enhances the activity.

A series of amine linked bis- and tris-heterocycles were prepared from heteroaryl cinnamamides and tested for antimicrobial activity. The compounds 11c and 12c exhibited excellent antibacterial activity while 12a and 12c displayed excellent antifungal activity.

A series of amine linked bis- and tris-heterocycles were prepared from heteroaryl cinnamamides and tested for antimicrobial activity. The compounds 11c and 12c exhibited excellent antibacterial activity while 12a and 12c displayed excellent antifungal activity.Figure optionsDownload as PowerPoint slide