Synthesis and biological evaluation of 1β-methylcarbapenems having cyclic thiourea moieties and their related compounds

The synthesis of a new series of 1β-methylcarbapenems having cyclic thiourea moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIId) having piperazine thiourea moiety showed the most potent antibacterial activity.

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