کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1395837 | 1501234 | 2006 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis, structure, toxicological and pharmacological investigations of 4-hydroxycoumarin derivatives Synthesis, structure, toxicological and pharmacological investigations of 4-hydroxycoumarin derivatives](/preview/png/1395837.png)
Twenty 4-hydroxycoumarin derivatives were synthesized. Five of them are described for the first time. The X-ray crystal structure analysis of 3,3′-(2,3,4-trimethoxyphenylmethylene)bis-(4-hydroxy-2H-1-benzopyran-2-one) (7) and 3,3′-(3,5-dimethoxy-4-hydroxyphenylmethylene)bis-(4-hydroxy-2H-1-benzopyran-2-one) (9) confirmed the structure of these compounds. A comparative pharmacological study of the anticoagulant effect with respect to Warfarin showed that the synthesized compounds have different anticoagulant activities. The most prospective compound is 3,3′-(4-chlorophenylmethylene)bis-(4-hydroxy-2H-1-benzopyran-2-one) (12) with low toxicity, very good index of absorption and dose dependent anticoagulant activity.
Twenty coumarin derivatives have been synthesized. The most prospective compound is 3,3′-(4-chlorophenylmethylene)bis-(4-hydroxy-2H-1-benzopyran-2-one) with low toxicity, very good index of absorption and dose-dependent anticoagulant activity in vivo.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 7, July 2006, Pages 882–890