کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1396138 1501173 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and antimicrobial properties of some new thiazolyl coumarin derivatives
چکیده انگلیسی

Two novel series of hydrazinyl thiazolyl coumarin derivatives have been synthesized and fully characterized by IR, 1H NMR, 13C NMR, elemental analysis and mass spectral data. The structures of some compounds were further confirmed by X-ray crystallography. All of these derivatives, 10a–d and 15a–h, were screened in vitro for antimicrobial activity against various bacteria species including Mycobacterium tuberculosis and Candida albicans. The compounds 10c, 10d and 15e exhibited very good activities against all of the tested microbial strains.

Hydrazinyl thiazolyl coumarin derivatives have been synthesized and screened for in vitro antimicrobial activities against different microbes including Mycobacterium tuberculosis.Figure optionsDownload as PowerPoint slideHighlights
► We synthesis new biologically active compounds with various pharmacophores.
► Structural confirmation of the synthesized compounds was done by various spectroscopic techniques.
► All compounds exhibited notable antimicrobial activities against different bacteria including Mycobacterium tuberculosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 46, Issue 9, September 2011, Pages 3788–3794
نویسندگان
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