کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1396251 | 1501183 | 2010 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of bioactive polyheterocyclic ring systems as 5α-reductase inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis of bioactive polyheterocyclic ring systems as 5α-reductase inhibitors Synthesis of bioactive polyheterocyclic ring systems as 5α-reductase inhibitors](/preview/png/1396251.png)
چکیده انگلیسی
Simple synthetic strategies for the hitherto unreported [1,2,4]triazolo[4,3-a]pyrido[4,3-d]pyrimidines 8 and [1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-b][1,6]naphthyridine-5-one 15 are described based on reaction of thione 3 and 12 with hydrazonoyl chloride 1a–h, respectively. The structures of products 8 and 15 were confirmed by spectroscopic and X-ray crystallographic analyses. Also, the mechanism of such reactions was discussed. In addition, reaction of compound 12 with bromoacetic acid and hydrazine hydrate was investigated. Compounds were screened against 5α-reductase and showed activities with good LD50 and LD90 for all compounds.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 11, November 2010, Pages 4838–4844
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 11, November 2010, Pages 4838–4844
نویسندگان
Naglaa A. Abdel Hafez, Thoraya A. Farghaly, Mohamed A. Al-Omar, Mohamed M. Abdalla,