کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1396262 | 1501183 | 2010 | 6 صفحه PDF | دانلود رایگان |
The synthesis of milrinone analogues where the 4-pyridyl moiety was replaced by an ester or amide group is reported. Only amide derivatives are able to support intracellular calcium influx following chemical depolarization with 60 mM KCl in a percentage varying from 20 to 45% of differentiated H9C2 cardiomyocytes. Those cells were differentiated after chronic exposure to 10 nM retinoic acid which induces the expression of voltage-gated calcium channels. Analogues of milrinone containing an ester function did not show significant activity.
New milrinone analogues were synthesized by removing the 4-pyridyl moiety or replacing it with an ester or amide function and their ability to interfere with the [Ca2+]i level during the plasma membrane depolarization in H9C2 cardiomyocytes was tested.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 11, November 2010, Pages 4928–4933