کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1396312 | 1501183 | 2010 | 8 صفحه PDF | دانلود رایگان |
Eight new palladium(II) complexes (1a–2d) with 4-toluenesulfonyl-l-amino acid dianion and diimine (bipy and phen) have been synthesized and characterized by elemental analysis, IR, UV, 1H NMR, 13C NMR and mass spectra techniques. Crystal structure of the complex (2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays. The results indicate that the complexes (1a–2d) have selectivity against tested carcinoma cell lines. The complex (2c) has the best cytotoxicity among the eight complexes, moreover its cytotoxicity is better than that of cisplatin against BGC-823, Bel-7402 and KB cell lines. It suggests that both aromatic diimine and 4-toluenesulfonyl-l-amino acid have important effect on cytotoxicity.
Eight palladium(II) complexes (1a–2d) have been synthesized. Crystal structure of the complex (2d) has been determined by X-ray diffraction analysis. The cytotoxicity was tested by MTT and SRB assays.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 11, November 2010, Pages 5337–5344