Synthesis and anti-tubercular and antimicrobial activities of some 2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-one N-isonicotinoylhydrazone derivatives

Seven 2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-one N-isonicotinoylhydrazones 8-14 were synthesized from 2r,4c-diaryl-3-azabicyclo[3.3.1]nonan-9-one (1-7). All the synthesized compounds showed very good activity against MTB and INH-TB. Some of these compounds have shown significant antibacterial and antifungal activities.