کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1396405 | 1501187 | 2010 | 10 صفحه PDF | دانلود رایگان |
Six new diorganotin(IV) derivatives of N′-(2-hydroxybenzylidene)formohydrazide (H2L) with general formula R2SnL, where R = Ph (1), Me (2), Bu (3), Oct (4), t-Bu (5), Et (6), and L = [OC6H4CHNNCHO] have been synthesized and characterized by different analytical techniques. Crystal structure of Me2SnL (2) authenticated distorted square-pyramidal geometry around the Sn atom. The CV and UV–Vis spectroscopic data indicated intercalation of complexes into DNA with binding affinity varying in the sequence: 3 (1.69 × 104 M−1) > 1 (1.10 × 104 M−1) > 2 (9.61 × 103 M−1). Some of these compounds were found to be good antibacterial, antifungal and leishmanicidal agents.
Six new diorganotin(IV) derivatives of N′-(2-hydroxybenzylidene)formohydrazide (H2L) have been synthesised and characterized. These compounds have good DNA binding ability.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 7, July 2010, Pages 2902–2911