Synthesis and evaluation of some new benzothiazole derivatives as potential antimicrobial agents

As benzothiazole has proven to be good antimicrobial agent, a novel series of Schiff bases of benzothiazole derivatives were synthesized. Thus condensation of 5-[2-(1,3-benzothiazol-2-yl-amino) ethyl]-4-amino-3-mercapto-(4H)-1,2,4-triazole 5 with appropriate aromatic aldehydes afforded 5-[2-(1,3-benzothiazol-2-yl-amino)ethyl]-4-(arylideneamino)-3-mercapto-(4H)-1,2,4-triazoles 6a–g. Structures of the synthesized compounds were elucidated on the basis of elemental analyses and spectral data. All the synthesized compounds were screened for their antimicrobial activity.

A novel series of 5-[2-(1,3-benzothiazol-2-yl-amino) ethyl]-4-(arylideneamino)-3-mercapto-(4H)-1,2,4-triazoles 6a–g were synthesized and evaluated for their antimicrobial activity to identify potential compounds.Figure optionsDownload as PowerPoint slide