کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1396519 | 1501189 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antiviral activity of new acrylamide derivatives containing 1,2,3-thiadiazole as inhibitors of hepatitis B virus replication
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and antiviral activity of new acrylamide derivatives containing 1,2,3-thiadiazole as inhibitors of hepatitis B virus replication Synthesis and antiviral activity of new acrylamide derivatives containing 1,2,3-thiadiazole as inhibitors of hepatitis B virus replication](/preview/png/1396519.png)
چکیده انگلیسی
A series of new acrylamide derivatives containing 1,2,3-thiadiazole were synthesized, characterized, and evaluated for their anti-hepatitis B virus (HBV) activities in vitro. The IC50 of compounds 9b (10.4 μg/mL), 9c (3.59 μg/mL) and 17a (9.00 μg/mL) of the inhibition on the replication of HBV DNA were higher than that of the positive control lamivudine (14.8 μg/mL). Compound 9d exhibited significant activity against secretion of HBeAg (IC50 = 12.26 μg/mL).
A series of new acrylamide derivatives containing 1,2,3-thiadiazole were synthesized, characterized and tested in vitro against HBV. Some of the new compounds display excellent activity against DNA reproduction and against HBeAg of HBV.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 5, May 2010, Pages 1919–1926
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 5, May 2010, Pages 1919–1926
نویسندگان
Wei-Li Dong, Zheng-Xiao Liu, Xing-Hai Liu, Zheng-Ming Li, Wei-Guang Zhao,