Synthesis and biological evaluation of novel 4,5-bis(dialkylaminoalkyl)-substituted acridines as potent telomeric G-quadruplex ligands

Several 4,5-bis(dialkylaminoalkyl)-substituted acridines have been prepared starting from acridine and their telomeric G-quadruplex stabilizing properties were evaluated using FRET melting and TRAP (Telomerase Repeat Amplification Protocol Assay) experiments.

Some 4,5-bis(dialkylaminoalkyl)-substituted acridines have been prepared and their telomeric G-quadruplex stabilizing properties were evaluated.Figure optionsDownload as PowerPoint slide