کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1396605 1501196 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, spectroscopic characterization, X-ray structure and evaluation of binding parameters of new triorganotin(IV) dithiocarboxylates with DNA
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, spectroscopic characterization, X-ray structure and evaluation of binding parameters of new triorganotin(IV) dithiocarboxylates with DNA
چکیده انگلیسی

Three new triorganotin(IV) dithiocarboxylates (1–3) with general formula R3SnL, where R = C4H9 (1), C6H11 (2), C6H5 (3) and L = 4-(4-nitrophenyl)piperazine-1-carbodithioate, have been synthesized and characterized by elemental analysis, Raman, FT-IR, multinuclear NMR (1H, 13C and 119Sn) and mass spectrometry. The crystal structure of complex 3 confirmed distorted trigonal-bipyramidal geometry around Sn atom. The interaction of compounds 1–3 with DNA was investigated by cyclic voltammetry (CV) and UV–vis spectroscopy. The positive peak potential shift in CV and hypochromic effect in spectroscopy evidenced intercalative mode of interaction. The results indicate that the binding affinity varies in this sequence: 1 > 3 > 2.

Three new triorganotin(IV) dithiocarboxylates, have been synthesized and characterized. The interaction of compounds with DNA was investigated by cyclic voltammetry (CV) and UV–vis spectroscopy.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 10, October 2009, Pages 3986–3993
نویسندگان
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