Synthesis and antibacterial activity of novel 15-membered macrolide derivatives: 4″-Carbamate, 11,12-cyclic carbonate-4″-carbamate and 11,4″-di-O-arylcarbamoyl analogs of azithromycin

Three series of 15-membered macrolide analogs were designed, synthesized and evaluated for their antibacterial activities. Among them, 11,4″-di-O-arylalkylcarbamoyl analogs exhibited potent and balanced activity against susceptible and resistant bacteria.