کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1396903 1501207 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and aldose reductase inhibitory activity of some new chromonyl-2,4-thiazolidinediones
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and aldose reductase inhibitory activity of some new chromonyl-2,4-thiazolidinediones
چکیده انگلیسی

As it is known that still, there were no any confident ARIs on the market and they have several side effects, we need to approve new ARIs to reduce diabetic complications especially which have effect on the cataract formation. In this study, a new series of chromonyl-2,4-thiazolidinediones (Ia–e, IIa–e, IIIa–e) were prepared by Knoevenagel reaction with substituted 3-formylchromones (3a–e) and unsubstituted (1) or substituted 2,4-thiazolidinedione (2). The synthesized compounds were tested for their ability to inhibit rat kidney AR by an in vitro spectrophotometric assay. Compound IIIe showed the highest inhibitory activity (82.43 ± 0.76%). Compounds Ia–e and IIIa–d also showed significant inhibitory activity (42.40 ± 5.78, 52.71 ± 3.31, 49.69 ± 1.55, 50.80 ± 3.62, 46.70 ± 2.33, 49.44 ± 4.53, 61.17 ± 4.74, 68.58 ± 2.05, 77.28 ± 0.26%, respectively).

A series of chromonyl-2,4-thiazolidinediones (Ia–e, IIa–e, IIIa–e) were prepared by Knoevenagel reaction. The prepared compounds were tested for their aldose reductase inhibitory activities.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 11, November 2008, Pages 2412–2417
نویسندگان
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