کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1396903 | 1501207 | 2008 | 6 صفحه PDF | دانلود رایگان |

As it is known that still, there were no any confident ARIs on the market and they have several side effects, we need to approve new ARIs to reduce diabetic complications especially which have effect on the cataract formation. In this study, a new series of chromonyl-2,4-thiazolidinediones (Ia–e, IIa–e, IIIa–e) were prepared by Knoevenagel reaction with substituted 3-formylchromones (3a–e) and unsubstituted (1) or substituted 2,4-thiazolidinedione (2). The synthesized compounds were tested for their ability to inhibit rat kidney AR by an in vitro spectrophotometric assay. Compound IIIe showed the highest inhibitory activity (82.43 ± 0.76%). Compounds Ia–e and IIIa–d also showed significant inhibitory activity (42.40 ± 5.78, 52.71 ± 3.31, 49.69 ± 1.55, 50.80 ± 3.62, 46.70 ± 2.33, 49.44 ± 4.53, 61.17 ± 4.74, 68.58 ± 2.05, 77.28 ± 0.26%, respectively).
A series of chromonyl-2,4-thiazolidinediones (Ia–e, IIa–e, IIIa–e) were prepared by Knoevenagel reaction. The prepared compounds were tested for their aldose reductase inhibitory activities.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 43, Issue 11, November 2008, Pages 2412–2417