کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1396965 1501222 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthetic cinnamylphenol derivatives as cancer chemopreventive agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthetic cinnamylphenol derivatives as cancer chemopreventive agents
چکیده انگلیسی

Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives were synthesized and tested for their inhibitory activities against in vitro Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The prenylated cinnamylphenols were found to show remarkably potent activity. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These results indicate that some prenylated cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).

Several substituted cinnamylphenol (1,3-diphenylpropene) derivatives showed anti-tumor-promoting activity on Epstein-Barr virus early antigen activation induced by TPA in Raji cells. Furthermore, prenylated cinnamylphenols (19 and 25) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 42, Issue 7, July 2007, Pages 902–909
نویسندگان
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