Cyclopentanone ring-cleaved pleuromutilin derivatives

Ring-cleaved pleuromutilin derivatives comprised of a [5.3.1] bicyclic core structure have been synthesized and evaluated in vitro as antibacterial agents. Four of the compounds described were found to have MICs ≤ 4 μg/mL against marker strains of Streptococcus pneumoniae and Staphylococcus aureus.

Antibacterial pleuromutilin derivatives containing a bicyclic nucleus are described.Figure optionsDownload as PowerPoint slide