کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1397155 | 1501235 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antiproliferative effect of Baylis–Hillman adducts and a new phthalide derivative on human tumor cell lines
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
In this work we report our results concerning the study on the in vitro antiproliferative activity of 18 Baylis–Hillman adducts and some derivatives against a panel of humor tumor cell lines. A brief qualitative structure–activity relationship study indicated that carbon-carbon double bond and the presence of an electron-withdrawing substituent at the aromatic ring are essential for the activity. A quinoline–phthalide derivative has exhibited a potent effect on the proliferation of all cell lines. It is interesting to note their special cytotoxic activity against NCIADR cell line.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 6, June 2006, Pages 738–744
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 6, June 2006, Pages 738–744
نویسندگان
Luciana K. Kohn, C.H. Pavam, D. Veronese, F. Coelho, J.E. De Carvalho, Wanda P. Almeida,