کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1397213 1501114 2015 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Triazine as a promising scaffold for its versatile biological behavior
ترجمه فارسی عنوان
تریازین به عنوان یک داربست امیدوار کننده برای رفتار بیولوژیکی همه جانبه آن
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی


• Triazine showed multiple biological properties.
• Recent developments on medicinal aspects of triazine are discussed.
• Various activities viz., antitumor, antimalarial, antimicrobial etc. are mentioned.
• Structure–activity relationship studies of molecules have been defined.

Among all heterocycles, the triazine scaffold occupies a prominent position, possessing a broad range of biological activities. Triazine is found in many potent biologically active molecules with promising biological potential like anti-inflammatory, anti-mycobacterial, anti-viral, anti-cancer etc. which makes it an attractive scaffold for the design and development of new drugs. The wide spectrum of biological activity of this moiety has attracted attention in the field of medicinal chemistry. Due to these biological activities, their structure–activity relationship has generated interest among medicinal chemists and this has culminated in the discovery of several lead molecules. The outstanding development of triazine derivatives in diverse diseases within very short span of time proves its magnitude for medicinal chemistry research. Therefore, these compounds have been synthesized as target structure by many researchers, and were further evaluated for their biological activities. In this review, we have compiled and discussed the biological potential of s-triazine derivatives, which could provide a low-height flying bird's eye view of the triazine derived compounds to a medicinal chemist, for a comprehensive and target oriented information for the development of clinically viable drugs.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 102, 18 September 2015, Pages 39–57
نویسندگان
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