کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1397671 1501184 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners
چکیده انگلیسی

In an effort to discover new and effective chemotherapeutic agents from this laboratory for the treatment of tuberculosis, here in we describe the synthesis and biological evaluation of a series of novel benzothiadiazine 1,1-dioxide (BTD) based congeners by using rifampicin, streptomycin; ciprofloxacin and amphotericin as positive controls. Further, to understand structural requirements for exploring the structure activity relationship of BTDs, cytotoxicity and in vivo study of recently reported potent molecule 4 (MIC = 1 μg/mL) is also discussed.

A new series of benzothiadiazine 1,1-dioxide based congeners was synthesized and evaluated against Mycobacterium tuberculosis, Gram-positive, Gram-negative bacteria and fungi. Further, in vivo activity of earlier potent molecule of this series is also discussed.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 10, October 2010, Pages 4545–4553
نویسندگان
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