کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1397671 | 1501184 | 2010 | 9 صفحه PDF | دانلود رایگان |

In an effort to discover new and effective chemotherapeutic agents from this laboratory for the treatment of tuberculosis, here in we describe the synthesis and biological evaluation of a series of novel benzothiadiazine 1,1-dioxide (BTD) based congeners by using rifampicin, streptomycin; ciprofloxacin and amphotericin as positive controls. Further, to understand structural requirements for exploring the structure activity relationship of BTDs, cytotoxicity and in vivo study of recently reported potent molecule 4 (MIC = 1 μg/mL) is also discussed.
A new series of benzothiadiazine 1,1-dioxide based congeners was synthesized and evaluated against Mycobacterium tuberculosis, Gram-positive, Gram-negative bacteria and fungi. Further, in vivo activity of earlier potent molecule of this series is also discussed.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 10, October 2010, Pages 4545–4553