کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1397676 1501184 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological property of some novel 1,3,4-oxadiazoles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological property of some novel 1,3,4-oxadiazoles
چکیده انگلیسی

A series of biphenyl-1,3,4-oxadiazoles namely 5-[substituted-(1,1′-biphenyl)-3-yl]-1,3,4-oxadiazole-2(3H)-thiones and its S-alkyl derivatives have been synthesized by multi step organic synthesis involving Suzuki-Miyaura coupling using palladium catalyst. The synthesized compounds were characterized by 1H NMR, 13C NMR, 19F NMR, IR and LCMS spectroscopic properties. They were tested for their antimicrobial and analgesic activities. Some of them showed significant activity.

A novel series of 5-[substituted-(1,1’-biphenyl)-3-yl]-1,3,4-oxadiazole-2(3H)-thiones and their S-alkylated derivatives have been prepared through a multi step organic synthesis involving palladium catalyzed Suzuki-Miyaura coupling. The new compounds have been screened for their antibacterial, antifungal and analgesic activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 10, October 2010, Pages 4587–4593
نویسندگان
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