کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1397729 | 1501188 | 2010 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and molecular docking studies of 1-phenyl-4-glycosyl-dihydropyridines as potent antileishmanial agents
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of 1-phenyl-4-glycosyl-dihydropyridines (4–17 and 19–21) were prepared by the one pot multicomponent reaction of glcosyl aldehyde, β-keto compounds and aniline or substituted aniline in the presence of TBAHS as catalyst. The compounds were screened in vitro and in vivo for their antileishmanial activities. Most of the compounds exhibited moderate to good activity against amastigotes and promastigotes of Leishmania donovani. The compounds 4, 11, 12, 13, and 17 exhibited potent in vivo activity with selectivity index (SI) values 7.43–18.93. Molecular docking studies with these compounds revealed L. donovani PTR1 as the possible target to show antileishmanial activities.
Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 6, June 2010, Pages 2381–2388
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 6, June 2010, Pages 2381–2388
نویسندگان
Vivek Parashar Pandey, Surendra Singh Bisht, Mridul Mishra, Ashutosh Kumar, Mohammad Imran Siddiqi, Aditya Verma, Monika Mittal, Shraddha A. Sane, Suman Gupta, Rama P. Tripathi,