کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1397873 1501194 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Captopril and 6-mercaptopurine: Whose SH possesses higher antioxidant ability?
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Captopril and 6-mercaptopurine: Whose SH possesses higher antioxidant ability?
چکیده انگلیسی

Antioxidant capacities of captopril (CAP), 6-mercaptopurine (6-MP) and 9-(β-d-ribofuranosyl)-6-mercaptopurine (6-MPR) were investigated by interacting them with 2,2′-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical, and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) cation radical (ABTS+), and by protecting DNA and erythrocyte against 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH) induced oxidation. It was found that CAP possessed the highest ability to donate the hydrogen atom in –SH to DPPH and galvinoxyl, while 6-MPR had the strongest ability to reduce ABTS+. In the process of protecting DNA and erythrocytes against AAPH-induced oxidation, CAP can trap 0.5 and 1.3 radicals, 6-MP can trap 0.6 and 2.2, and 6-MPR can trap 1.0 and 3.0 radicals, respectively. CAP can also protect erythrocytes against hemin-induced hemolysis.

Antioxidant properties of captopril, 6-mercaptopurine and 9-(β-d-ribofuranosyl)-6-mercaptopurine were screened by protecting DNA and erythrocytes, and by interacting with radicals. The –SH group attached to aromatic ring possessed high antioxidant effectiveness.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 12, December 2009, Pages 4841–4847
نویسندگان
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