کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1397969 | 1501201 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Amines and oximes derived from deoxybenzoins as Helicobacter pylori urease inhibitors
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Twenty amines and oximes from deoxybenzoins were prepared and evaluated for their inhibitory activity against Helicobacter pylori urease. Among these compounds, high inhibitory activities were observed in amines and oximes, especially amines 1b (IC50 = 0.011 mM) and 6b (IC50 = 0.047 mM) exhibited good in vitro activities, and were comparable to acetohydroxamic acid (AHA). The hydroxyl groups on deoxybenzoin skeleton may be responsible for the inhibitory activity and coordinate with the nickel (active site) on enzyme. A direct interaction may exist between the OH group of hydroxylamines or NH group of amines and His α323 of H. pylori urease, which is on the flap of the enzyme active site.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 5, May 2009, Pages 2246–2251
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 5, May 2009, Pages 2246–2251
نویسندگان
Huan-Qiu Li, Zhu-Ping Xiao, Yin-Luo, Tao Yan, Peng-Cheng Lv, Hai-Liang Zhu,