Synthesis and antimicrobial activity of new 1-alkyl/cyclohexyl-3,3-diaryl-1′-methylspiro[azetidine-2,3′-indoline]-2′,4-diones

The paper describes the synthesis of new 1-alkyl/cyclohexyl-3,3-diaryl-1′-methylspiro[azetidine-2,3′-indoline]-2′,4-diones from the reactions of the 2-diazo-1,2-diarylethanones with 1-methyl-3-(alkyl/cyclohexylimino)indolin-2-ones under thermal condition. The compounds, characterized by satisfactory analytical and spectral (IR, 1H NMR and 13C NMR) data, have been screened for their antibacterial and antifungal activities.

A series of 10 new spiro[azetidine-2,3′-indoline]-2′,4-diones have been synthesized by ketene–imine cycloadditon and evaluated for their antibacterial and antifungal activities.Figure optionsDownload as PowerPoint slide