کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1398029 | 1501205 | 2009 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Possible anticancer agents: QSAR analogs of glutamamide: Synthesis and pharmacological activity of 1,5-N,Nâ²-disubstituted-2-(substituted benzenesulphonyl) glutamamides
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Based on our earlier QSAR prediction, a series of QSAR analogs of 1,5-N,Nâ²-disubstituted-2-(substituted benzenesulphonyl) glutamamides were synthesized, pharmacologically evaluated and QSAR analysis of these compounds was performed. The study showed importance of particular atoms in dispersive interaction of the compounds with the enzymes, as well as the substitution patterns required for improved activity which may offer an opportunity for further tailoring of these analogs for an active member.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 1, January 2009, Pages 70-82
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 1, January 2009, Pages 70-82
نویسندگان
Soma Samanta, Sk. Mahasin Alam, Parthasarathi Panda, Tarun Jha,