کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1398049 | 1501205 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A QSAR study for the cytotoxic activities of taxoids against macrophage (MΦ)-like cells
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
A series of taxoids (modified at the C-3′N position) have been used for the development of two QSAR models for their cytotoxic activities against macrophage (MΦ)-like cells J774.1 and J7.DEF3. QSAR results suggest that hydrophobic and steric features influence the inhibitory activity in a linear model. The C log P values were not great enough to establish the upper limit of the inhibition. Internal [cross-validation, quality factor (Q), Fischer statistics (F), Y-randomization, and lack of overfitting tests] and external validation tests have validated both the QSAR models.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 1, January 2009, Pages 274–279
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 1, January 2009, Pages 274–279
نویسندگان
Corwin Hansch, Rajeshwar P. Verma,