کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1398069 | 1501205 | 2009 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
2,3-Disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines: A novel class of antitumor agents
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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![عکس صفحه اول مقاله: 2,3-Disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines: A novel class of antitumor agents 2,3-Disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines: A novel class of antitumor agents](/preview/png/1398069.png)
چکیده انگلیسی
A series of 2,3-disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines were synthesized and evaluated for their cytotoxic activity in vitro against five human cancer cell lines (human lung carcinoma cell line: A549, human leukemia cell lines: K562 and Molt-4, human prostate cancer cell line: PC-3, human breast carcinoma cell line: MDA-MB-231). Most of these compounds show potent activity against these tumor cell lines, especially against the A549 cell line. The cell cycle analysis was also studied by flow cytometry measurement on A549 cell line.
The cytotoxic activity of 2,3-disubstituted 8-arylamino-3H-imidazo[4,5-g]quinazolines in vitro against human lung cell lines is reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 1, January 2009, Pages 448–452
Journal: European Journal of Medicinal Chemistry - Volume 44, Issue 1, January 2009, Pages 448–452
نویسندگان
Yandong Zhang, Zhe Chen, Yijia Lou, Yongping Yu,