کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1398182 | 1501218 | 2007 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines Biopartitioning micellar chromatography to predict mutagenicity of aromatic amines](/preview/png/1398182.png)
Mutagenicity is a toxicity endpoint associated with the chronic exposure to chemicals. Aromatic amines have considerable industrial and environmental importance due to their widespread use in industry and their mutagenic capacity.Biopartitioning micellar chromatography (BMC), a mode of micellar liquid chromatography that uses micellar mobile phases of Brij35 in adequate experimental conditions, has demonstrated to be useful in mimicking the drug partitioning process into biological systems. In this paper, the usefulness of BMC for predicting mutagenicity of aromatic amines is demonstrated. A multiple linear regression (MLR) model based on BMC retention data is proposed and compared with other ones reported in bibliography. The proposed model present better or similar descriptive and predictive capability.
In this paper the usefulness of BMC for predicting aromatic amines' mutagenicity is demonstrated.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 42, Issues 11–12, November–December 2007, Pages 1396–1402