کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1398284 1501238 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
QSAR studies on benzopyran potassium channel activators
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
QSAR studies on benzopyran potassium channel activators
چکیده انگلیسی
QSAR studies on a series of benzopyrans as potassium channel activators have been carried out using a large set of distance-based topological indices. In addition, the molecular descriptors namely: negentropy and molecular redundancy indices have also been used. The relaxant potency in rat trachea, expressed as pEC50 was used for biological characterization of the benzopyrans. The results have shown that pEC50 can be modeled excellently in multiparametric model in that we have to include an indicator parameter. The predictive powers of the proposed models are discussed on the bases of cross-validation parameters.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 41, Issue 3, March 2006, Pages 360-366
نویسندگان
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