Synthesis, antimycobacterial and antibacterial activity of fluoroquinolone derivatives containing an 3-alkoxyimino-4-(cyclopropylanimo)methylpyrrolidine moiety

A series of novel fluoroquinolone derivatives were synthesized. 19b2 showed good activity against MTB/MDR-MTB strains. 22b1 was more potent than levofloxacin against Gram-positive strains including MRSA and MRSE.