Enantiopure antituberculosis candidates synthesized from (−)-fenchone

• 17 new enantiopure amide derivatives of (−)-fenchone were synthesized.
• 3 compounds possess in vitro antimycobacterial activity near than activity of EMB.
• The most active compound is less cytotoxic.

The synthesis of new enantiopure N-acyl compounds derived from (−)-fenchone has been performed. The evaluation of their in vitro activity against Mycobacterium tuberculosis H37Rv showed for most of them moderate activity. The structures bearing sulfonamide functionality have comparable activity to ethambutol and possess low cytotoxicity.

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