Novel acetamidothiazole derivatives: Synthesis and in vitro anticancer evaluation

• A novel series of acetamide derivatives of 2-imino-4-arylthiazoles was prepared.
• Twelve compounds were selected and tested for their anticancer activities by NCI.
• Compounds 5a and 6b proved promising for further development.

A novel series of acetamide derivatives possessing both 2-imino-4-arylthiazoles and morpholine or different piperazines were synthesized and characterized by IR, 1H NMR, 13C NMR, elemental and mass spectral analyses. Twelve compounds were granted NSC codes at National Cancer Institute (NCI), USA for anticancer activity at a single high dose (10−5 M) in full NCI 60 cell panel. Among the compounds tested, compounds 5a and 6b were found to be the most active candidates of the synthesized series. Assessment of toxicities, druglikeness, and drug score profiles of compounds 5a and 6b are promising. Some of the synthesized compounds showed a good docking score with potential anticancer targets, chosen based on pharmacophore mapping of the established derivatives.

The manuscript deals with the synthesis of a novel series of 2-imino-4-arylthiazoles bearing acetamidomorpholine or acetamidopiperazine moieties to be evaluated for their anticancer activities.Figure optionsDownload as PowerPoint slide