کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399062 | 1501147 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel promising linezolid analogues: Rational design, synthesis and biological evaluation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
• 5-Substituted oxazolidinones linezolid analogues were synthesized.
• Docking studies of linezolid (thio)urea derivatives were performed.
• Compound 10f demonstrated an activity comparable to that of linezolid.
A new series of 5-substituted oxazolidinones derived from linezolid, having urea and thiourea moieties at the C-5 side chain of the oxazolidinone ring, were prepared and their in vitro antibacterial activity was evaluated. The compound 10f demonstrated high antimicrobial activity, comparable to that of linezolid against Staphylococcus aureus.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 69, November 2013, Pages 779–785
Journal: European Journal of Medicinal Chemistry - Volume 69, November 2013, Pages 779–785
نویسندگان
Margherita De Rosa, Anna Zanfardino, Eugenio Notomista, Thomas A. Wichelhaus, Carmela Saturnino, Mario Varcamonti, Annunziata Soriente,