کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1399072 1501151 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity
چکیده انگلیسی


• A novel series of chalcones, flavanones and flavones have been synthesized.
• Compounds 1a, 1e–g, 2e–g, 3j, and 4f showed potent anti-inflammatory activity.
• Most potent compound 1f showed very mild inhibition against COX-1 and COX-2.
• Compound 1f also significantly inhibited the TNF-α level.

A novel series of synthetic 2′-hydroxychalcones (1a–h), 2′-methoxychalcones (2a–l), flavanones (3a–k) and flavones (4a–f) have been synthesized and evaluated for their anti-inflammatory activity in carrageenan induced rat paw oedema model. Compounds 1a, 1e–g, 2e–g, 3j, and 4f showed potent anti-inflammatory activity comparable to the reference drug indomethacin with insignificant ulceration. Compound 1f showed mild inhibition against the enzymatic activity of ovine COX-1 and COX-2 (in-vitro). Compound 1f also exhibited inhibitory activity in LPS induced TNF-α production.

Anti-inflammatory activity of synthesized novel flavonoid derivatives was evaluated. Most active compound 1f showed mild inhibition on the activity of COX-1 and COX-2 enzymes and significantly inhibited the TNF-α level.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 65, July 2013, Pages 51–59
نویسندگان
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