کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1399086 1501151 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis, antitumor and antibacterial activities of some novel tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis, antitumor and antibacterial activities of some novel tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives
چکیده انگلیسی


• Two series of fused thieno[2,3-d]pyrimidines were synthesized.
• They were tested for their antitumor and antibacterial activities.
• 3-Acridinyl derivatives had potent antitumor and antibacterial activities.

Two series of new tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines namely 2,3-disubstituted derivatives 3a–z and 2,4-disubstituted ones 6a–c were prepared and tested for their antitumor and antibacterial activities. The structures of the prepared compounds were confirmed by spectral and elemental analyses. Compound 3z exhibited the highest antitumor activity against breast MCF-7 with IC50 = 0.19 μM compared to Doxorubicin (IC50 = 5.46 μM), while 3r was the most active one against liver HEPG-2 cancer cell line with IC50 = 1.29 μM as regard to Doxorubicin (IC50 = 7.36 μM). Concerning the antibacterial activity, compounds 3m and 3z exerted remarkable activity against the tested bacterial species compared to Ampicillin, whereas compound 6c showed good activity against only Gram positive species.

The target compounds 3a–z and 6a–c were prepared and tested for their antitumor and antibacterial activities. Compounds 3z and 3r exerted the highest activity against MCF-7 and HEPG-2 cell lines, respectively.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 65, July 2013, Pages 195–204
نویسندگان
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