کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399222 | 1501153 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation and antimalarial activity of semisynthetic lycorenine derivatives
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
• A series of lycorenine derivatives were synthesized.
• The compounds were evaluated for their in vitro antimalarial activity.
• Some structure–activity relationships were outlined.
• The best activities were achieved with the dimeric derivatives.
A set of twenty one lycorenine derivatives has been prepared from the alkaloid hippeastrine (1). The modifications performed on hippeastrine included some functional group transformations, structural simplification and preparation of dimers. All alkaloids were tested as potential antimalarial agents, being the hippeastrine dimers the most active compounds.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 63, May 2013, Pages 722–730
Journal: European Journal of Medicinal Chemistry - Volume 63, May 2013, Pages 722–730
نویسندگان
Juan C. Cedrón, David Gutiérrez, Ninoska Flores, Ángel G. Ravelo, Ana Estévez-Braun,