کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1399237 | 1501153 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Microwave-assisted synthesis of arene ruthenium(II) complexes that induce S-phase arrest in cancer cells by DNA damage-mediated p53 phosphorylation
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Microwave-assisted synthesis of arene ruthenium(II) complexes that induce S-phase arrest in cancer cells by DNA damage-mediated p53 phosphorylation Microwave-assisted synthesis of arene ruthenium(II) complexes that induce S-phase arrest in cancer cells by DNA damage-mediated p53 phosphorylation](/preview/png/1399237.png)
چکیده انگلیسی
⺠A series of arene Ru(II) complexes were synthesized under microwave irradiation. ⺠The crystal structure of complex 1b gives a typical “piano stool” conformation. ⺠These complexes exhibit acceptable antitumor activities but low cytotoxicity. ⺠S-phase arrest of MG-63 cells induced by complex 2b was determined. ⺠DNA damage triggered by complex 2b was identified.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Medicinal Chemistry - Volume 63, May 2013, Pages 57-63
Journal: European Journal of Medicinal Chemistry - Volume 63, May 2013, Pages 57-63
نویسندگان
Qiong Wu, Cundong Fan, Tianfeng Chen, Chaoran Liu, Wenjie Mei, Sidong Chen, Baoguo Wang, Yunyun Chen, Wenjie Zheng,