کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1399483 | 1501186 | 2010 | 9 صفحه PDF | دانلود رایگان |
A series of novel organoselenocyanate compounds (6a–d) having spiro[tetralin-1,3′-pyrrolidine] moiety were synthesized. The compounds were evaluated for their inhibitory activity against cadmium- (Cd) induced toxicity in Swiss Albino mice. All the compounds (6a–d) inhibited the level of lipid peroxidation (LPO) and upregulated the activity of glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH) levels in treatment group in comparison to the untreated Cd control group. Serum transaminase activities, e.g., alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also significantly lowered in the compound-treated mice. Elongation of the alkyl chain length bearing the selenocyanate (SeCN) active group enhanced the potency of the compounds, 6d being the most active one (6d > 6c > 6b > 6a).
A series of spiro[6-methoxytetralin-1,3′-pyrrolidine] based organoselenocyanates were synthesized and evaluated against cadmium induced lipid peroxidation and hepatotoxicity in mice.Figure optionsDownload as PowerPoint slide
Journal: European Journal of Medicinal Chemistry - Volume 45, Issue 8, August 2010, Pages 3265–3273